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Use with caution in patients with mild renal impairmentFor patients with moderate renal impairmentreduce dose or increase interval between dosesSuch patients should be carefully monitored for adverse effects of colchicinesee also section 5.2

If you are taking colchicine to treat FMFyour doctor may start you on a low dose and gradually increase your doseYour doctor may decrease your dose if you experience side effects.

Colchicine can prevent attacks of gout and control FMF only as long as you take the medicationContinue to take colchicine even if you feel wellDo not stop taking colchicine without talking to your doctor.

Because of the increased incidence of decreased renal function in the elderly populationand the higher incidence of other co-morbid conditions in the elderly population requiring the use of other medicationsreducing the dosage of colchicine when elderly patients are treated with colchicine should be carefully considered.

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